Search Result

Search Results for " kallikrein inhibitor "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T14358	Avoralstat	BCX4161	Others
	Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.		Others
T11885	LSP-249		Others
	LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell.		Others
T39350	Sebetralstat	KVD900	Others
	Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.		Others
T6370	AEBSF hydrochloride	AEBSF HCl,Pefabloc SC	Thrombin , Serine Protease , Influenza Virus
	AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.		Thrombin , Serine Protease , Influenza Virus
T3359	Aprotinin	Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others , Serine Protease , Influenza Virus , Proteasome
	Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...		Others , Serine Protease , Influenza Virus , Proteasome
TP1792L	KKI-5 acetate(97145-43-2 free base)		Serine Protease
	KKI-5 acetate is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema.		Serine Protease
T0372	Gabexate mesylate	FOY	Factor Xa , Serine Protease , Proteasome
	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh...		Factor Xa , Serine Protease , Proteasome
T68173	ZD-2138	Ici-D2138	Lipoxygenase
	ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolat...		Lipoxygenase
T63796	Kallikrein-IN-2
	Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.
T40312	Plasma kallikrein-IN-1
	Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.
T63579	Kallikrein-IN-1
	Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.
T70161	Berotralstat HCl
	Berotralstat HCl is a novel selective inhibitor of plasma kallikrein, blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated wi...
T61403	Plasma kallikrein-IN-3
	Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].
T71417	LM-030
	LM-030, also known as BPR277, is a novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2).
T80271	Irucalantide
	Irucalantide is a kallikrein inhibitor [1].
T72337	Plasma kallikrein-IN-2
	Plasma kallikrein-IN-2, a potent inhibitor of plasma kallikrein (PKal) with an inhibitory concentration (IC) 50 value of 0.1 nM, is utilized in research targeting hereditary angioedema, diabetic macular edema, and diabet...
T35579	PKSI-527
	PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respect...
T72624	Kallikrein 5-IN-2
	Kallikrein 5-IN-2 is a potent inhibitor of Kallikrein KLK5, exhibiting selectivity with a pIC50 value of 7.1. By inhibiting KLK5, it has the potential to normalize epidermal shedding, thereby reducing associated inflamma...
T63507	Feniralstat
	Feniralstat is a pyrazole derivative, a potent inhibitor of kallikrein, which inhibits human plasma kinase (pKal) (IC50: 6.7 nM).Feniralstat does not inhibit human KLK1, human FXIa and human factor Xlla (IC50 >40 μM).
T77999	KKI-5 TFA
	KKI-5 (TFA), a specific tissue kallikrein inhibitor, has been shown to inhibit breast cancer cell invasion [1].
T69777	DKFZ-251
	DKFZ-251 is a potent inhibitor of kallikrein-related peptidase 6 with on-target cellular activity. DKFZ-251 demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay.
T80095	D-Pro-Phe-Arg-Chloromethylketone		Factor Xa
	D-Pro-Phe-Arg-Chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, is significant in the regulation of thrombosis and inflammation [1].		Factor Xa
T35869	Berotralstat
	Berotralstat (BCX7353) is a second-generation, synthetic, and orally active plasma kallikrein inhibitor with low toxicity. It is highly specific and effectively used in the research of hereditary angioedema (HAE) attacks...
T82510	Ecallantide TFA	DX-88 TFA
	Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of acute angioedema attacks [1].
TP1792	KKI-5
	KKI 5 is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema.
T6564L	Leupeptin	Leupeptin Ac-LL,NK-381
	Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), ...
T69297	Leupeptin HCl
	Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin...
T76248	Tutuilamide A
	Tutuilamide A, a potent inhibitor of porcine pancreatic elastase (PPE) with an IC50 of 1.2 nM, also effectively inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM) [1].
T78572	Ecallantide	DX-88
	Ecallantide (DX-88) is a recombinant inhibitor specifically targeting plasma kallikrein, which serves to impede the synthesis of bradykinin. It is utilized to prevent acute episodes of angioedema [1].
T70170	Milvexian TFA
	Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 ...

Compounds

Synonym: AEBSF HCl,Pefabloc SC

Target: Thrombin, Serine Protease, Influenza Virus

Aprotinin

T3359

Synonym: Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin

Target: Others, Serine Protease, Influenza Virus, Proteasome

KKI-5 acetate(97145-43-2 free base)

TP1792L

Synonym:

Target: Serine Protease

Gabexate mesylate

T0372

Synonym: FOY

Target: Factor Xa, Serine Protease, Proteasome

Plasma kallikrein-IN-1

Plasma kallikrein-IN-3

Plasma kallikrein-IN-2

D-Pro-Phe-Arg-Chloromethylketone

Synonym: Leupeptin Ac-LL,NK-381

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00931	Serpin A4 Protein, Human, Recombinant (His)	Human	Human Cells
	Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and sec...
TMPH-00661	Ecotin Protein, E. coli O127:H6, Recombinant (His & Myc)	E. coli	E. coli
	General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
TMPJ-00891	Kallikrein 2/KLK2 Protein, Human, Recombinant (His)	Human	Human Cells
	Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave ...
TMPJ-01064	Serpin G1 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement sy...
TMPK-01158	Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulat...
TMPH-02832	Serpin A5 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extr...
TMPH-03119	SERPINB1 Protein, Pig, Recombinant (His & Myc)	Sus scrofa (Pig)	E. coli
	Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the ...
TMPY-02859	TFPI2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotei...
TMPY-02242	Serpin B6 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-...
TMPY-02329	TFPI2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotei...
TMPY-01004	TFPI2 Protein, Human, Recombinant (His)	Human	HEK293
	Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotei...
TMPJ-00502	Serpin G1 Protein, Human, Recombinant (His)	Human	Human Cells
	As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein...
TMPY-01598	Kininogen 1 Protein, Human, Recombinant (His)	Human	HEK293
	Kininogen-1, also known as high molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1, and BDK, is a secreted protein that contains three cystatin do...
TMPY-01606	Kininogen 1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Kininogen-1, also known as high molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1, and BDK, is a secreted protein that contains three cystatin do...